FMS-like tyrosine kinase 3 ligand
The Flt3l is a small molecule that acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3L is crucial for steady-state pDC and cDC development.[1] A lack of FLT3L results in low levels of DCs.
References
- ^ Shortman, Ken; Naik, Shalin H. (2006). "Steady-state and inflammatory dendritic-cell development". Nature Reviews Immunology 7 (1): 19–30. doi:10.1038/nri1996. PMID 17170756.
Further reading
- Robinson, S N; Chavez, J M; Pisarev, V M; Mosley, R L; Rosenthal, G J; Blonder, J M; Talmadge, J E (2003). "Delivery of Flt3 ligand (Flt3L) using a poloxamer-based formulation increases biological activity in mice". Bone Marrow Transplantation 31 (5): 361–9. doi:10.1038/sj.bmt.1703816. PMID 12634727.